Li-alkyne li teng haholo lihlahisoa tsa tlhaho, limolek'hule tse sebetsang ka biologically le lisebelisoa tse sebetsang tsa manyolo.Ka nako e ts'oanang, ke li-intermediate tsa bohlokoa ho organic synthesis 'me li ka ba le liphetoho tse ngata tsa lik'hemik'hale.Ka hona, nts'etsopele ea mekhoa e bonolo le e sebetsang ea kaho ea alkynes e potlakile haholo ebile e hlokahala.Le hoja karabelo ea Sonogashira e hlahisoang ke litšepe tsa phetoho e le e 'ngoe ea litsela tse sebetsang ka ho fetisisa le tse bonolo tsa ho kopanya aryl kapa alkenyl substituted alkynes, karabelo ea ho kopanya e kenyelletsang li-alkyl electrophiles tse sa sebetseng ke ka lebaka la liketso tse ka thōko tse kang bH ho felisoa.E ntse e tletse liqholotso le lipatlisiso tse fokolang, haholo-holo tse lekanyelitsoeng ho li-alkanes tse sa rateheng tikolohong le tse turang tsa halogenated.Ka hona, tlhahlobo le nts'etsopele ea karabelo ea Sonogashira ea li-alkylation reagents tse ncha, tse theko e tlaase le tse fumanehang habonolo e tla ba tsa bohlokoa bo boholo ka har'a li-laboratory synthesis le lisebelisoa tsa indasteri.Sehlopha se ile sa qapa ka bohlale 'me sa hlahisa mofuta o mocha, o fumanehang habonolo le o tsitsitseng oa mofuta oa NN2 pincer ligand, oo ka lekhetlo la pele o ileng oa hlokomela khetho e sebetsang le e phahameng ea lihlahisoa tsa alkylamine le li-alkyne tsa terminal tse nang le mehloli e mengata ea lisebelisoa tsa nickel, tse theko e tlaase le tse bonolo ho li etsa. fumana.Phetoho ea ho kopanya e 'nile ea sebelisoa ka katleho ho phetoho ea morao-rao ea deamination le alkynylation ea lihlahisoa tse rarahaneng tsa tlhaho le limolek'hule tsa lithethefatsi, e leng se totobatsang ts'ebetso e ntle ea karabelo le ho lumellana ha sehlopha se sebetsang,' me e fana ka ntho e ncha bakeng sa ho qaptjoa ha alkyne ea bohlokoa e nkeloang sebaka.Le mekhoa e sebetsang.
Nako ea poso: Nov-22-2021